South Africa fits a city, wine country and a serious safari into one trip. Fly overnight to Cape Town, spend a few days between Table Mountain, the Atlantic beaches and the Cape Peninsula, then drive an hour to the vineyards of Franschhoek or Stellenbosch. A short flight takes you to the private reserves on Kruger's western edge.
The Sabi Sand and its neighbours are known for leopards that are unusually relaxed around vehicles, habituated over decades and followed off-road by tracker and guide. For young children, the malaria-free Madikwe and the Eastern Cape reserves are good alternatives.
The time difference is one or two hours, so there is no jet lag to speak of. The caveat is personal security in the cities: we plan transfers door to door and advise where to walk.